ATBioInfo Antimicrobial & LOINC Reference
Endocrinology & Metabolic Bioinformatics • LOINC 4548-4

HbA1c, Fasting Insulin (HOMA-IR) & South Asian Cardiometabolic Risk Biomarkers

Glycated hemoglobin (HbA1c), HOMA-IR insulin resistance modeling, triglyceride-to-HDL ratio, and ethnic-specific BMI/waist circumference cutoffs.

CLSI Susceptibility / Reference Standard: HbA1c Normal: < 5.7% | Prediabetes: 5.7–6.4% | Diabetes: >= 6.5% | South Asian Normal BMI: 18.5–22.9 kg/m²

Glycated Hemoglobin (HbA1c, LOINC 4548-4) reflects time-averaged blood glucose concentrations over the preceding 90–120 days of erythrocyte lifespan. In South Asian and Asian populations, visceral adiposity, hepatic steatosis, and beta-cell dysfunction emerge at significantly lower body mass index thresholds (BMI ≥ 23.0 kg/m2 for overweight and ≥ 25.0 kg/m2 for obesity) compared to European cohorts.

Related Clinical Practice & Patient Interpretation Guidelines:
• South Asian vs. Global WHO BMI & Waist-to-Height Ratio Calculator
• Zenodo DOI: South Asian Cardiometabolic Risk Stratification Dataset